Dr Susan Sandeman
Pharmacy and Biomolecular Sciences
Telephone: +44 (0)1273 642053
+44 (0)1273 641635
Dr Sandeman is a Reader in Biomaterials with an interest in materials based approaches to moderate inflammation and infection and is Director of Postgraduate Studies for Life, Health and Physical Sciences. She has worked in the field of biomaterials science since obtaining her PhD in 1999 and enjoys the challenges of a career integrating biomaterials research with academic oversight of science PhD students; investing in the next generation of research scientists.
How I like to teach
I teach on subjects related to biomaterials science. My early teaching experience was first year undergraduate teaching in biological sciences and then in special topics modules on inflammation and haemocompatibility. I currently teach on subjects related to medical device technologies, ophthalmic biomaterials and tissue regeneration. I also lead research methodologies and research communication skills units within the University Research Development Framework for postgraduate research students.
My research interests
My research interests are broadly focused on the use of biomaterials strategies to moderate inflammation and infection; generating a better understanding and ability to manipulate cell-biomaterial interactions for long-term health benefit. I undertake research into nanostructured carbons for biomedical applications, biomedical device technologies related to the treatment of organ failure, smart biomaterial approaches to control infection, inflammation and oxidative stress, cell scaffolds, corneal biomaterials and tissue engineering.
Current research projects:
- Principal Investigator for University of Brighton (UCL Coordinator). Horizon 2020 Research and Innovation Framework Programme grant entitled 'Clinical evaluation of a nanoporous carbon adsorbent with tailored porosity (Yaq-001) as a new therapeutic for the treatment of liver cirrhosis and non-alcoholic fatty liver disease' (CARBALIVE). 1/5/15-30/10/19. €5,934,484.
- Principal Investigator. British Council funded Global Innovation Award entitled 'Nanostructured materials for the control of contaminants detrimental to health' (NOMAD). 1/4/2014 - 31/3/2016. £146,915.
- Principal Investigator. EU FP7 Marie Curie Industry-Academia partnerships and pathways (IAPP) project. 'Adsorbent carbons for the removal of biological toxins' (ACROBAT). 1/12/12- 30/11/16. €1451,705.
Previous research projects as PI or Co-I:
- Principal Investigator. National Institute for Health Research i4i project entitled 'An adsorbent device to promote toxin removal during haemodialysis' (ADEPT). 1/2/13 -31/1/15. £378,234.
- Co-investigator. TSB:Sepsis II: advancing biomarker use in sepsis management. Validation of protein biomarkers to diagnose the early onset of sepsis. 1/6/12 - 31/8/14. £389,550.
- Co-investigator. Kidney Research UK funded project 'A Pilot Study to Investigate the Effects of Oral Mesoporous Carbon on Organic Azotaemic Toxins and Chronic Kidney Disease'. 1/1/12- 31/3/13 £38,601.
- Principal Investigator. Brighton Business Investment Fund award entitled 'Mesospherical oral carbon for the treatment of liver disease' 12/2010- 12/2011 £32,480.
- Principal Investigator. National Institute for Health Research i4i FPD1 project entitled 'The optimization of a novel carbon adsorbent filtration device to augment renal replacement therapy' (DART) 6/2010- 8/2011. £99,040.
I completed my PhD in 1999 looking at factors which affect cell interactions with novel biomaterials for corneal tissue replacement. I progressed from research fellow to Reader working on projects related to my research in ophthalmic biomaterials and then in adsorbent and smart polymer biomaterials as medical devices for organ replacement. I began an additional role working as Deputy Director of Postgraduate Studies in 2013 and then as Director of Postgraduate studies in 2015. I currently combine research activities in the Biomaterials and Medical Devices research group with academic oversight of PhD students as Director of Postgraduate Studies for Life, Health and Physical Sciences.
Author of over 30 peer reviewed journal articles and co-inventor on 3 patents
Rayner Intraocular Lenses Ltd
Yishan Zheng, PhD entitled Hybrid filtration adsorbent systems for extracorporeal applications, (2009-12)
Elsie Fok, PhD entitled The development of advanced corneal epithelial stem cell delivery systems for the treatment of corneal epithelial defects, (2009-13)
Dr Vankata Avadhanam, MD entitled 'Clinico-radiological study of OOKP lamina and development of a synthetic lamina' (4/2013 -current)
Miss Tochukwu Ozulumba, PhD entitled 'Nanostructured scaffolds for remediation of environmental and biological tissue contaminants' (10/15 -)
Miss Jessica Cooper, PhD entitled 'Engineering a bioartificial liver prototype using cell loaded macroporous hydrogel scaffolds' (10/15 -)
Within the University as Director of Postgraduate Studies for Life, Health and Physical Sciences I am a member of the Doctoral College Board and associated committees and am independent chair for PhD viva examinations. Within the School of Pharmacy and Biomolecular Sciences I represent the Biomaterials research group at the school research strategy committee.
External to the University I sit on the Newton Fund Biomedical Sciences grant review panel and on the Global Innovation Initiative grant review panel for the British Council (2014 - current), I act as a grant reviewer for the UK BBSRC, am editor for the Journal of Biomaterials and Tissue Engineering, BioMed Research International, am journal referee for a number of biomaterials journals, a member of the European Society for Biomaterials, the European Society for Artificial Internal Organs and the Kent, Sussex and Surrey Renal Research Network.
Patani Gold Medal for excellence awarded by the School of Pharmacy and Biomolecular Sciences for best PhD thesis, University of Brighton (1999)
University of Brighton Innovation Award (2005) for work developing a novel carbon device for the treatment of sepsis
Ingavle, Ganesh, Baillie, Les W.J., Zheng, Yishan, Lis, Elzbieta K., Savina, Irina, Howell, Carol, Mikhalovsky, Sergey and Sandeman, Susan (2015) Affinity binding of antibodies to supermacroporous cryogel adsorbents with immobilized protein A for removal of anthrax toxin protective antigen Biomaterials, 50. pp. 140-153. ISSN 0142-9612
Fok, Elsie, Sandeman, Susan, Guildford, Anna and Martin, Y.H. (2015) The use of an IL-1 receptor antagonist peptide to control inflammation in the treatment of corneal limbal epithelial stem cell deficiency BioMed Research International, 2015. ISSN 2314-6133
Sandeman, Susan, Howell, Carol, Phillips, Gary, Zheng, Yishan, Standen, Guy, Pletzenauer, Robert, Pletzenauer, Andrew, Basnayake, Kolitha, Owen, Boyd, Holt, Stephen and Mikhalovsky, Sergey (2014) An adsorbent monolith device to augment the removal of uraemic toxins during haemodialysis Journal of Materials Science: Materials in Medicine, 25 (6). pp. 1589-1597. ISSN 0957-4530
Weng, Tingting, Jianwei, Guo, Xinming, L., Yingde, C., Xuejiao, Yang, Zhang, Kun, Zhang, Buning, Yin, Guoqiang, Mikhalovsky, Sergey, Mikhalovska, Lyuba, Savina, Irina, Howell, Carol and Sandeman, Susan (2014) Synthesis of the polymerizable room temperature ionic liquid AMPS – TEA and superabsorbency for organic liquids of its copolymeric gels with acrylamide Designed Monomers and Polymers, 17 (2). pp. 140-146. ISSN 1385-772X
Weng, Tingting, Jianwei, Guo, Xinming, L., Yingde, C., Zhang, Buning, Mikhalovsky, Sergey, Sandeman, Susan, Howell, Carol, Mikhalovska, Lyuba and Savina, Irina (2014) Synthesis, Chloramphenicol Uptake, and In Vitro Release of Poly(AMPS–TEA-Co-AAm) Gels with Affinity for Both Water and Alcohols International Journal of Polymeric Materials, 63 (2). pp. 73-79. ISSN 0091-4037
Howell, Carol, Sandeman, Susan, Phillips, Gary, Mikhalovsky, Sergey, Tennison, S.R., Rawlinson, A.P. and Kozynchenko, O.P. (2013) Nanoporous activated carbon beads and monolithic columns as effective hemoadsorbents for inflammatory cytokines International Journal of Artificial Organs, 36 (9). pp. 624-632. ISSN 0391-3988
Howell, Carol, Mikhalovsky, Sergey, Sandeman, Susan, Jalan, Rajiv and Macnaughtan, Jane (2013) Porous carbon particles for use in the treatment or prevention of liver disease .
Huhtinen, Reeta, Sandeman, Susan, Rose, Susanna, Fok, Elsie, Howell, Carol, Froberg, Linda, Moritz, Niko, Hupa, Leena and Lloyd, Andrew (2013) Examining porous bio-active glass as a potential osteo-odonto-keratoprosthetic skirt material Journal of Materials Science: Materials in Medicine, 24 (5). pp. 1217-1227. ISSN 0957-4530
Zheng, Yishan, Gun'ko, V.M., Howell, Carol, Sandeman, Susan, Phillips, Gary, Kozynchenko, O.P., Tennison, S.R., Ivanov, A.E. and Mikhalovsky, Sergey (2012) Composites with macroporous poly(vinyl alcohol) cryogels with attached activated carbon microparticles with controlled accessibility of a surface ACS Applied Materials and Interfaces, 4 (11). pp. 5936-5944. ISSN 1944-8244
Mikhalovsky, Sergey, Sandeman, Susan, Howell, Carol, Phillips, Gary and Nikolaev, V.G. (2012) Biomedical applications of carbon adsorbents In: Tascon, Juan, ed. Novel carbon adsorbents. Elsevier, Oxford, UK, pp. 639-669. ISBN 9780080977447
Presser, Volker, Yeon, Sun-Hwa, Vakifahmetoglu, Cekdar, Howell, Carol, Sandeman, Susan, Colombo, Paolo, Mikhalovsky, Sergey and Gogotsi, Yury (2012) Hierarchical porous carbide-derived carbons for the removal of cytokines from blood plasma Advanced Healthcare Materials, 1 (6). pp. 796-800. ISSN 2192-2640
Macnaughtan, Jane, Soeda, J., Mouralidarane, A., Sandeman, Susan, Howell, Carol, Mikhalovsky, Sergey, Kozynchenko, O.P., Tennison, S.R., Davies, N., Mookerjee, R. and Jalan, Rajiv (2012) Effects of oral nanoporous carbon therapy in leptin null mice as a model of non-alcoholic steatohepatitis In: Digestive Disorders Federation Meeting, Liverpool, 17–20 June 2012.
Macnaughtan, Jane, Soeda, J., Mouralidarane, A., Sandeman, Susan, Howell, Carol, Kozynchenko, S., Mikhalovsky, Sergey, Tennison, S.R., Davies, N., Mookerjee, R., Oben, J. and Jalan, Rajiv (2012) Oral administration of nanoporous carbons reduce severity of non-alcoholic steatohepatitis by modulating hepatic kupffer cell function: a novel therapeutic approach In: Abstracts of The International Liver Congress 2012, 2012.
Sandeman, Susan, Petersson, Malin, Wiezell, Sara, Howell, Carol, Phillips, Gary, Zheng, Yishan, Tennison, S.R., Kozynchenko, O.P. and Mikhalovsky, Sergey (2012) Characterising nanoporous carbon adsorbents for biological application to chronic kidney disease Journal of Biomaterials and Tissue Engineering, 2 (1). pp. 40-47. ISSN 2157-9091
Tripisciano, C., Kozynchenko, O.P., Linsberger, I., Phillips, Gary, Howell, Carol, Sandeman, Susan, Tennison, S.R., Mikhalovsky, Sergey, Weber, V. and Falkenhagen, D. (2011) Activation-dependent adsorption of cytokines and toxins related to liver failure to carbon beads Biomacromolecules, 12 (10). pp. 3733-3740. ISSN 1525-7797
Howell, Carol and Sandeman, Susan (2011) Carbon adsorbents for blood purification .
Sandeman, Susan, Gun'ko, V.M., Bakalinksa, O.M., Howell, Carol, Zheng, Y., Kartel, M.T., Phillips, Gary and Mikhalovsky, Sergey (2011) Adsorption of anionic and cationic dyes by activated carbons, PVA hydrogels, and PVA/AC composite Journal of Colloid and Interface Science, 358 (2). pp. 582-592. ISSN 0021-9797
Yachamaneni, Saujanya, Yushin, Gleb, Yeon, Sun-Hwa, Gogotsi, Yury, Howell, Carol, Sandeman, Susan, Phillips, Gary and Mikhalovsky, Sergey (2010) Mesoporous carbide-derived carbon for cytokine removal from blood plasma Biomaterials, 31 (18). pp. 4789-4794. ISSN 0142-9612
Sandeman, Susan, Jeffery, H., Howell, Carol, Smith, Martin, Mikhalovsky, Sergey and Lloyd, Andrew (2009) The in vitro corneal biocompatibility of hydroxyrapatite coated carbon mesh Biomaterials, 30 (18). pp. 3143-3149. ISSN 0142-9612
Sandeman, Susan, Jeffery, Hannah, Howell, Carol, Smith, Martin, Mikhalovsky, Sergey and Lloyd, Andrew (2009) The in vitro corneal biocompatibility of hydroxyapatite coated carbon mesh Biomaterials, 30 (18). pp. 3143-3149. ISSN 0142-9612
Xinming, L., Yingde, C., Lloyd, Andrew, Mikhalovsky, Sergey, Sandeman, Susan, Howell, Carol and Liewen, L. (2008) Polymeric hydrogels for novel contact lens-based ophthalmic drug delivery systems: a review Contact Lens and Anterior Eye, 31 (2). pp. 57-64. ISSN 1367-0484
Sandeman, Susan, Howell, Carol, Mikhalovsky, Sergey, Phillips, Gary, Lloyd, Andrew, Davies, G.J., Tennison, S.R., Rawlinson, A.P. and Kozynchenko, O.P. (2008) Inflammatory cytokine removal by an activated carbon device in a flowing system Biomaterials, 29 (11). pp. 1638-1644. ISSN 0142-9612
Yushin, G., Hoffman, E., Barsoum, M.W., Gogotsi, Y., Howell, Carol, Sandeman, Susan, Phillips, Gary, Lloyd, Andrew and Mikhalovsky, Sergey (2006) Mesoporous carbide-derived carbon with porosity tuned for efficient adsorption of cytokines Biomaterials, 27 (34). pp. 5755-5762. ISSN 0142-9612
Howell, Carol, Sandeman, Susan, Phillips, Gary, Lloyd, Andrew, Davies, J.G., Mikhalovsky, Sergey, Tennison, S.R., Rawlinson, A.P., Kozynchenko, O.P., Owen, H.L.H., Gaylor, J.D.S., Rouse, J.J. and Courtney, J.M. (2006) The in vitro adsorption of cytokines by polymer-pyrolysed carbon Biomaterials, 27 (30). pp. 5286-5291. ISSN 0142-9612
Sandeman, Susan, Howell, Carol, Phillips, Gary, Lloyd, Andrew, Davies, J.G., Mikhalovsky, Sergey, Tennison, S.R., Rawlinson, A.P., Kozynchenko, O.P., Owen, H.L.H., Gaylor, J.D.S., Rouse, J.J. and Courtney, J.M. (2005) Assessing the in vitro biocompatibility of a novel carbon device for the treatment of sepsis Biomaterials, 26 (34). pp. 7124-7131. ISSN 0142-9612
Mehta, J.S., Futter, C.E., Sandeman, Susan, Faragher, Richard, Hing, K.A., Tanner, K.E. and Allan, B.D.S (2005) Hydroxyapatite promotes superior keratocyte adhesion and proliferation in comparison with current keratoprosthesis skirt materials British Journal of Ophthalmology, 89 (10). pp. 1356-1362. ISSN 0007-1161
Sandeman, Susan, Lloyd, Andrew, Tighe, B.J., Franklin, V., Li, J., Lydon, F., Liu, C.S.C., Mann, D.J., James, S.E. and Martin, R. (2003) A model for the preliminary biological screening of potential keratoprosthetic biomaterials Biomaterials, 24 (26). pp. 4729-4739. ISSN 0142-9612
Eleftheriadis, H., Cheong, M., Sandeman, Susan, Syam, P.P., Brittain, P., Klintworth, G.K., Lloyd, Andrew and Liu, C. (2002) Corneal toxicity secondary to inadvertent use of benzalkonium chloride preserved viscoelastic material in cataract surgery British Journal of Ophthalmology, 86 (3). pp. 299-305. ISSN 0007-1161
Sandeman, Susan, Faragher, Richard, Allen, Marcus, Liu, C. and Lloyd, Andrew (2001) Does MMP-2 expression and secretion change with increasing serial passage of keratocytes in culture? Mechanisms of Ageing and Development, 122 (2). pp. 157-167. ISSN 0047-6374
Dropcova, S., Denyer, Stephen, Lloyd, Andrew, Gard, Paul, Hanlon, Geoff, Mikhalovsky, Sergey, Sandeman, Susan, Olliff, C.J. and Faragher, Richard (1999) A standard strain of human ocular keratocytes Ophthalmic Research, 31 (1). pp. 33-41. ISSN 0030-3747